A Complete Workflow Solution for Intact Monoclonal Antibody Characterization Using a New High-Performance Benchtop Quadrupole-Orbitrap LC-MS/MS

Poster Note 64778 Top-down Characterization of Monoclonal Antibody on an Orbitrap Fusion Lumos™ Tribrid Mass Spectrometer Seema Sharma, Stephane Houel, Christopher Mullen, Chad Weisbrod, Romain Huguet, John Syka, Dave Horn, Jonathan Josephs, Jae Schwartz, Vlad Zabrouskov Thermo Fisher Scientific, San…

experiments were performed yielding 100% sequence coverage, site specific information of the drug-conjugate as well as expected and unexpected modifications. 10 21 0 Methods Sample Preparation M N LC Poster Note 643 97 The T-DM1 sample was reduced by DTT…

Martin Samonig1,2, Christian Huber1,2 and Kai Scheffler2,3 1 Division of Chemistry and Bioanalytics, University of Salzburg, Salzburg, Austria 2 Christian Doppler Laboratory for Innovative Tools for Biosimilar Characterization, University of Salzburg, Salzburg, Austria 3 Thermo Fisher Scientific, Dreieich, Germany Key…

APPLICATION NOTE 73885 Complete characterization of monoclonal antibodies under native and denaturing conditions Kristina Srzentić1, Eugen Damoc2, Kai Scheffler3, Tom Buchanan4, Krisztina Radi4, Jennifer Sutton1 Thermo Fisher Scientific, 1 Cambridge, Massachusetts, US 2 Bremen, Germany 3 Germering, Germany 4 Hemel…