Advanced host cell protein (HCP) analysis with TIMS QTOF MS powers biopharmaceutical development

In Depth Analysis of Host Cell Proteins from Antibody Preparations using PASEF Introduction In the rapidly expanding arena of biotherapeutic analysis and bioprocess development, the analysis of host cell proteins (HCPs) at the ppm level is critical. ELISA is currently…

timsTOF Pro with PASEF and Evosep One: Maximizing throughput, robustness and analytical depth for shotgun proteomics The timsTOF Pro powered by PASEF enables sequencing speed of > 120 Hz, high sensitivity and robustness as well as an additional dimension of…

High throughput 4D-Proteomics – Application of dia-PASEF® and the Evosep One for short gradients The timsTOF Pro offers a combination of two unique technologies, namely a 4th dimension provided by Trapped Ion Mobility Spectrometry (TIMS) to enhance ion separation and…

FlashNote Same Day HCP Workflow Has Become Reality! Host cell proteins (HCPs) are process-related impurities encountered in biotherapeutic drug development. Presence of HCPs in the final drug product, even at very low levels, can affect drug efficacy and stability, and…