Highly Selective and Sensitive Method for Quantification of Nitrosamines in Valsartan Drug Substances

Analysis of Genotoxic Nitrosamines in Losartan and Ranitidine Active Pharmaceutical Ingredients On the SCIEX QTRAP® 4500 LC-MS/MS System with ExionLC™ AD System Sandeep Choudhary, Aman Sharma, M Chandrasekar, Manoj Pillai SCIEX, India In recent years, there have been several high…

APPLICATION NOTE 000235 Simultaneous quantitation of nine nitrosamines using a highly sensitive and LC-HRAM mass spectrometry method in multiple drug products Authors: Krishna Mane, Pratip Saha, Venkatesh Chanukuppa, Biswajayee Patra, Saravanan Kumar Thermo Fisher Scientific, Bengaluru, India Keywords: Nitrosamine quantitation,…

Nitrosamine Impurities Application Guide Confidently Detect and Quantify Mutagenic Impurities in APIs and Drug Products Sartan-Based Losartan Valsartan Candesartan Telmisartan Metformin Ranitidine Nitrosamines are formed by chemical reactions that occur during API manufacturing whether from starting materials, intermediates, reactants, reuse…

Application note | 003215 Pharma Highly sensitive method for the determination of 12 nitrosamine impurities in multiple ARBs, the class of sartan drug formulations Application benefits Authors Varun Khali , Manoj Kushwaha , Dr. Sachin 1 1 • Single method…