Microflow Chromatography: A Key to More Sensitive Met ID

A P P LICAT ION SOLUT IONS FO R M ETABOLIT E IDENT IFICAT ION A P P L I C AT I O N S O L U T I O N S F O R M E TA…

Streamlining Discovery Microsomal Clearance and Metabolite ID Analysis using a TripleTOF® 6600 System SWATH® Acquisition 2.0 for Small Molecule Applications Mustafa Varoglua*, Lieu Nguyena, Xiaowei Hea**, Keith J. Goodmanb a Cubist Pharmaceuticals, Lexington, MA, bSCIEX, Framingham, MA, Present address: *Alnylam…

Application News No. Liquid Chromatography Mass Spectrometry High-Sensitivity Analysis of Drugs in Ultra-Small Volume Plasma Samples Using Microflow LC/MS/MS C213 It is known that drugs and other xenobiotics are generally subject to metabolism in the body, which facilitates their detoxification…

ThP151 High Sensitivity Identification of Drug Metabolites with Increasing Ionization Efficiency using A Novel LC-ESI Interface and Q-TOF Yohei Arao1, Jeffrey Dahl1, Yuka Fujito1 1 Shimadzu Scientific Instruments, Inc. 7102 Riverwood Drive, Columbia, Maryland, 21046 USA 1. Introduction Direct Connection…