TMSI - Product Specification

TMSI+Pyridine Product Specification TMSI (N-trimethylsilylimidazole) is the strongest reagent for hydroxyls. It reacts quickly and smoothly with hindered and unhindered hydroxyl and carboxyl groups. TMSI+Pyridine is useful for derivatizing wet sugar samples, hindered hydroxyl groups in steroids and, in conjunction…

N-t-Butyldimethylsilylimidazole Product Specification N-t-Butyldimethylsilylimidazole (TBDMSIM) is formed by reacting butyldimethylchlorosilane and imidazole (1:2). Although TBDMSIM is not widely used, the t-butyldimethylsilyl (TBDMS) derivatives it forms enhance thermal stability and increase the inertness of the analyte(s). A weak silylating reagent, TBDMSIM…

TMCS Product Specification TMCS (trimethylchlorosilane) is a silylation catalyst, rarely used alone in analytical applications but typically mixed with other silylation reagents to increase their reactivity (e.g., HMDS/TMCS/ pyridine, BSTFA/TMCS, BSA/TMCS) in derivatization of alcohols, alkaloids, amines, biogenic amines, carboxylic…

Bulletin 909A Guide to Derivatization Reagents for GC A large number of reagents are used to prepare derivatives for gas chromatography, but most of the derivatization reactions fit into one of three categories: acylation, alkylation, or silylation. This bulletin describes…