Extending the Lower Limits of Quantification of a Therapeutic Oligonucleotide Through Microflow LC-MS/MS

Improve Sensitivity for Quantification of Antisense Oligonucleotides in Plasma Using Microflow LC-MRM Methodology Ji Jiang, Sean McCarthy, Esme Candish, Lei Xiong SCIEX, 500 Old Connecticut Path, Framingham, MA 01520 INTRODUCTION Oligonucleotide therapeutics are rapidly growing as a class of therapeutic…

Gene Therapy and Oligonucleotide Compendium Volume 1 Gene Therapy and Oligonucleotide Compendium Contents Introduction 4 Growing trends and emerging technologies for oligonucleotide and gene therapies 6 The global gene therapy & oligonucleotide market 8 Regional landscape North America EMEAI (Europe,…

Sensitive Quantification of Therapeutic Oligonucleotides Extracted from Plasma Featuring the SCIEX QTRAP® 6500+ LC-MS/MS System Esme Candish1, Ji Jiang1, Andrew Hart2, Susovan Mohapatra2 1 SCIEX, Framingham MA, USA, 2 Wave Life Sciences, Lexington, MA, USA Oligonucleotide therapeutics and gene therapies…

Ultra-Sensitive Quantification of Trastuzumab Emtansine in Mouse Plasma using Trap-Elute MicroLC MS Method Featuring SCIEX QTRAP® 6500+ System with OptiFlow™ Turbo V source and M5 MicroLC system Lei Xiong, Ji Jiang, and Remco van Soest SCIEX, Redwood City, California, USA…