A Sensitive and Cost-Effective LC–MS Method for Quantifying N-Nitroso-Atenolol in Drug Formulation

Application note | 003910 Pharma Liquid chromatography – high-resolution mass spectrometry method for determination of NDSRI in six beta-blocker drug substances Authors Application benefits Varun Khali1, Manoj Kushwaha1, • A single high-resolution-based method to determine the NDSRI level in a…

[ BROCHURE ] SUPPORTING THE CHALLENGE OF NITROSAMINE DRUG SUBSTANCE RELATED IMPURITIES ANALYSIS N-Nitrosamines are potentially mutagenic impurities that may pose a risk of cancer to humans when exposed over a prolonged period. Since 2018, global regulatory bodies have required…

Application Note Quantitation of N-Nitroso-DesmethylDiltiazem, an NDSRI Impurity of Diltiazem Hydrochloride in Drug Product Using LCMS/MS Pavan Kukkadapua, Marian Twohigb, Padmakar Wagha a Waters Corporation, Bangalore, India b Waters Corporation, Milford, United States Published on August 19, 2026 Abstract Since…

Application Note Analytical Scale Isolation and Purification of Propranolol Impurities Including Nitrosamine Drug Substance Related Impurity (NDSRI) Margaret Maziarz, Paul Rainville, Stephanie Harden Waters Corporation, United States Published on Novemebr 07, 2025 Abstract Nitrosamine drug substance-related impurities (NDSRIs) are a…