AUTOMATED LC/MS/MS HIGH THROUGHPUT MULTI-MODE IONIZATION QUANTIFICATION PROTOCOL APPLIED FOR MICROSOME STABILITY TEST IN DRUG DISCOVERY AND DEVELOPMENT

[ INSTRUMENT SPECIFICATIONS ] Xevo TQD The Waters™ Xevo™ TQD is an advanced benchtop tandem quadrupole mass detector designed for ultra high performance LC-MS/MS applications. With a wide range of ionization options including Atmospheric Pressure Photo Ionization (APPI), Atmospheric Pressure…

[ INSTRUMENT SPECIFICATIONS ] Xevo TQ-S Xevo® TQ-S is an advanced benchtop tandem quadrupole mass spectrometer, designed to meet the needs of your most demanding quantitative LC-MS/MS applications. Xevo TQ-S features revolutionary off-axis StepWave™ ion transfer optics that dramatically increases…

Application Note Analytical Solutions for High Throughput ADME Studies Marian Twohig, Robert S. Plumb, Amy Bartlett, Peter Hancock Waters Corporation Abstract High throughput ADME (absorption, distribution, metabolism, and elimination) plays a critical role in identifying viable drug candidates in the…

This article is licensed under CC-BY 4.0 pubs.acs.org/ac Article Ultrahigh-Performance Supercritical Fluid Chromatography−Multimodal Ionization−Tandem Mass Spectrometry as a Universal Tool for the Analysis of Small Molecules in Complex Plant Extracts Katerǐ na Plachká, Veronika Pilarǒ vá, Š tefan Kosturko, Jan…