In-depth peptide mapping of biopharmaceuticals using an electron-transfer/higher-energy collision dissociation (EThcD) implemented on a modified Orbitrap hybrid MS

Mass spectrometry Discover. Innovate. Exceed. Orbitrap Excedion Pro Mass Spectrometers Discover. Innovate. Exceed. Welcome to the next generation of mass spectrometry with Thermo Scientific™ Orbitrap™ Excedion™ Pro hybrid mass spectrometers (MS). Building on our outstanding legacy quadrupole-Orbitrap mass spectrometry technology,…

Complete characterization of KADCYLA using a new Orbitrap Excedion Pro BioPharma hybrid mass spectrometer with electron-transfer/higher-energy collision dissociation (EThcD) fragmentation Xiaoxi Zhang1, Roberto Gamez2, Reiko Kiyonami3, Cong Wang4, Peter Krueger4, Heiner Koch4, Min Du3 1 Thermo Fisher Scientific, Shanghai, China;…

Technical note | 004377 Mass spectrometry Advancing phosphorylation, ADMA, and O-GlcNAc PTM analysis with HCD and EThcD on the Orbitrap Excedion Pro mass spectrometer Authors Goal Mikayla Shanafelt1, Brett Larsen2, Demonstrate fast and sensitive performance of the Thermo Scientific™ Orbitrap™…

Implementation of Electron-transfer dissociation (ETD) and Electron-transfer/higher-energy collision dissociation (EThcD) on a modified Orbitrap hybrid MS Peter Krüger1, Hanno Resemann1, Erik Couzijn1, Andreas Kühn1, Cong Wang1, Jan-Peter Hauschild1, 1Thermo Fisher Scientific, Bremen, Germany Abstract Instrumental setup Purpose: Electron-transfer dissociation (ETD)…