Analysis of bispecific and multispecific antibody therapeutics using native mass spectrometry on a modified hybrid Orbitrap mass spectrometer

Aggregates analysis of a bispecific antibody using Orbitrap Excedion Pro BioPharma Hybrid mass spectrometer with extended mass range Xiaoxi Zhang1, Reiko Kiyonami2, Weijing Liu3, Xuepu Li1, Min Du2. 1 Thermo Fisher Scientific, Shanghai, China. 2 Thermo Fisher Scientific, Massachusetts, US…

Top-down sequencing of bispecific antibodies by electron capture dissociation on a timsOmni platform Iuliia Stroganova1,2, Simon Ollivier1,2, Jean-François Greisch1,5, Athanasios Smyrnakis3, Mariangela Kosmopoulou3, Detlev Suckau4, Dimitris Papanastasiou3 and Albert J.R. Heck1,2 1Biomolecular Mass Spectrometry & Proteomics, NL, 2Netherlands Proteomics Center,…

High Throughput Screening and Characterization of Bispecifics Using Native Ion Mobility Mass Spectrometry Caroline S. Te-Wei Gregory O Patrick D Andy Christian Carol H. 1Agilent Technologies, Santa Clara, CA; 2Agilent Technologies, La Jolla, CA; 3Agilent Technologies, Wilmington, DE 4 x10…

Technical note | 002786 Biopharma Increased sensitivity and throughput for native intact mass analysis using a NativePac OBE-1 SEC column and an Orbitrap Ascend Tribrid mass spectrometer Application benefits Authors Reiko Kiyonami , Weijing Liu , Rosa Viner , 1…