Offline tandem MSn workflows on the timsOmni platform for deep sequencing of intact proteins and mAbs

AS MS 2 0 2 5 – M P 4 7 1 Advances in hardware design and function of the new timsOmni MS platform D. Papanastasiou1; A. Smyrnakis1; M. Kosmopoulou1; A. Grigoriadis1; I. Orfanopoulos1; N. Manolis1; I. Panagiotopoulos1; R. Gioves1;…

T HP 645 ASM S 2026 Location, Location, Location… Native Top-Down Mass Spectrometry Provides Binding Site Information for Protein-Ligand and ProteinProtein Interactions Results and Discussion  High density electron beam from hot cathode 1Fasmatech Science & Technology, Chalandri, Greece; 2Bruker…

Poster Reprint ASMS 2024 Poster number ThP 025 Top-Down CDR Sequencing of Native Intact mAbs Through Deconvolution of HC+LC Mixture Spectra Lily E. Miller1; Stephanie Sturgeon2; Yury V. Vasilev2; Rachel Franklin2; Blake Hakkila2; Timothy Djang3; Alex Gavrilenko3; Jhenya Gavrilenko3; Panos…

Top‐Down Mapping of Protein Modifications by Multimodal MSⁿ on the New timsOmni Platform Francis Berthias1, Nurgül Bilgin2, Athanasios Smyrnakis3, Mariangela Kosmopoulou3, Christian Albers4, Jasmin Mecinović2, Dimitris Papanastasiou3, and Ole N. Jensen1 1 Department of Biochemistry and Molecular Biology; 2 Department…