Small-Footprint Capillary UHPLC/MS Technology Significantly Reducing Consumption of PFAS Containing Modifiers for Fast and High-Resolution Separation of Synthetic Oligonucleotides

Poster Reprint ASMS 2023 Poster number ThP 576 Oligo Purity Analysis and Sequence Confirmation by LC/MS without Ion Pairing Reagents — Sample to reports in about 5 minutes Guannan Li1, Peter Rye2 , Vaughn Miller2 and Thomas Walker2 1Agilent Technologies,…

Poster Reprint ASMS 2026 MP 514 Characterizing the Poly(A) tail in mRNA using Ion-Pairing Reversed-Phase LC/MS (IPRP-LC/MS) and Deconvolution Tools Stephen Sciuto1, Mike Knierman2, Thomas Walker3, Brian Rivera1 1Agilent Technologies, Santa Clara, CA 2Agilent Technologies, Gary, IN 3 Agilent Technologies,…

Application Note Biopharma Analysis of Oligonucleotides Using Ion-Pairing Alternatives on the Agilent Pro iQ Plus Authors Lee Bertram and Brian Rivera Agilent Technologies, Inc. Abstract This application note presents a practical approach for medium- to high-throughput molecular confirmation of synthetic…

APPLICATION BRIEF 74058 Characterization of a synthetic double stranded siRNA using high-resolution mass spectrometry Authors: Haichuan Liu1, Kevin Guo2, Julia Baek3, Jennifer Sutton1, Keeley Murphy1, Min Du2 Thermo Fisher Scientific, San Jose, CA 1 2 Thermo Fisher Scientific, Cambridge, MA…