Stability of enzyme quaternary structure analyzed by static and dynamic light scattering

I TEE PPAAPPEERR WWHHI T WP1615: SEC-MALS for absolute biophysical characterization Daniel Some, Ph.D., Waters | Wyatt Technology Summary Accurate characterization of biomacromolecules is essential for successful programs of research and development in the life sciences and biopharmaceuticals. The basic…

Volume 28, Number 1 Technical Article by Dan Some and Amy Hanlon Characterizing Protein–Protein Interactions Via Static Light Scattering: Inhibition Kinetics and Dissociation Q uantification of the kinetic rates of protein association, dissociation, and aggregation is an essential factor in…

PEG-Protein Interactions for Stable Formulations Studied by CG-MALS Daniel Some and Sophia Kenrick, Wyatt Technology Corp., Santa Barbara, CA 93117 1. Background Many therapeutic proteins such as antibodies exhibit non-specific self-association at concentrations > 10 mg/mL typical of final drug-product…

W H I T E PA P E R WP9007: Characterizing vaccines with light scattering Camille Lawrence, Ph.D., Waters | Wyatt Technology Introduction Vaccines are an indispensable weapon in the fight against human and animal disease, and countless lives have…