WADC: High Resolution Mass Spectrometry of Antibody Drug Conjugates Using the Orbitrap Mass Analyzer

Poster Note 64 8 0 2 Complete Characterization of a Cysteinelinked Antibody-Drug Conjugate Performed on a Hybrid Quadrupole-Orbitrap Mass Spectrometer with High Mass Range Aaron O. Bailey , Eugen Damoc , Stephaneof Houela , Kai Scheffler , Jonathan L. Josephs…

A comprehensive CE/ESI-MS solution for BioPharma applications Thermo Scientific Q Exactive hybrid quadrupole-Orbitrap mass spectrometers with ZipChip system Fast CE Separation Nanospray Sensitivity HRAM Spectrometry A unique and powerful combination of CE/ESI and MS technology designed for BioPharmaceutical applications Thermo…

APPLICATION NOTE 72511 Complete characterization of a lysine-linked antibody drug conjugate by native LC/MS intact mass analysis and peptide mapping Authors Aaron O. Bailey,1 Stephane Houel,1 Kai Scheffler,2 Eugen Damoc,3 Jennifer Sutton,1 Jonathan L. Josephs1 Thermo Fisher Scientific 1 San…

Application Note Biopharma/Pharma Characterization of Antibody‑Drug Conjugates Using 2D-LC and Native MS Authors David L. Wong and Sarah M. Stow Agilent Technologies, Inc. Abstract Antibody drug conjugates (ADCs), which comprise a monoclonal antibody (mAb) conjugated to a small molecule drug…