Quality control of oligonucleotides using HPLC coupled to UV and MS detection

Science with Passion Targeted LC-MS/MS detection of lipid impurities in lipid nanoparticles M. Prüfer, G. Greco; [email protected] KNAUER Wissenschaftliche Geräte GmbH, Hegauer Weg 38, 14163 Berlin; www.knauer.net SUMMARY Lipid nanoparticles (LNPs) became famous for the rapid development and largescale production…

TECHNICAL NOTE 73670 Quality control of oligonucleotides with a single quadrupole mass spectrometer Author: Stephan Meding Thermo Fisher Scientific, Germering, Germany Keywords: Single quadrupole mass spectrometer, ISQ EM, Vanquish Flex Binary, Chromeleon CDS, intact mass deconvolution Goal Show the benefit…

Table of contents Fast Track to Certainty: Confident Biopharma Decisions with LC-Single Quadrupole Mass Detection How single quadrupole LC/MS simplifies identification, purification, and stability assessment in biopharma Table of Contents Introduction��������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������� 3 Consolidating Biopharma QC Workflows: LC/UV Versus Single Quadrupole…

[ APPLICATION NOTEBOOK ] APPLICATION SOLUTIONS FOR OLIGONUCLEOTIDES Table of Contents Introduction – UPLC Analysis of Synthetic Oligonucleotides......................................................................................................................... 4 [ HPLC & UPLC Separations ] Real-Time Analysis of RNAi Duplexes ....................................................................................................................................................................... 8 Semi-Preparative Scale Single-Stranded RNA Purification .......................................................................................................................... 11 Oligonucleotide…