High-throughput and sensitive HPLC analysis of lipids used in LNP formulations with evaporative light scattering detection

Science with Passion Targeted LC-MS/MS detection of lipid impurities in lipid nanoparticles M. Prüfer, G. Greco; [email protected] KNAUER Wissenschaftliche Geräte GmbH, Hegauer Weg 38, 14163 Berlin; www.knauer.net SUMMARY Lipid nanoparticles (LNPs) became famous for the rapid development and largescale production…

Application Note Biopharma/Pharma Easy Column Screening for Lipid Nanoparticle Component Analysis Method development with the Agilent Biocompatible 6-Column Selector Valve and 1260 Infinity II Prime Bio LC System Author Sonja Schneider Agilent Technologies, Inc. Abstract The composition of lipid nanoparticles…

Application Note High-Throughput LNP Compositional Analysis Using GTxResolve™ RP 230 Å PH+ Columns: Method Development Considerations Mateusz Imiolek, Stephan M. Koza Waters Corporation, United States Published on June 08, 2026 Abstract This application note introduces a new GTxResolve Reversed Phase…

Application Note High-Throughput LNP Compositional Analysis Using GTxResolve™ RP 230 Å PH+ Columns: Robustness and Reproducibility Mateusz Imioleka, Stephan M. Kozab a Waters Corporation, Geneva, Switzerland b Waters Corporation, Milford, MA, United States Published on June 08, 2026 Abstract This…