Flexible nanoparticle development: process optimization & scale-up of a wide range of synthetic nanomedicines with Sunshine

APPLICATION NOTE Process optimization and pre-clinical production of lipid nanoparticles using Sunshine Introduction optimizing the conditions for producing nanoparticles can be laborious and resource intensive. For instance, ethanol injection is commonly employed to synthesize mRNA-LNPs, in which lipids suspended in…

APPLICATION NOTE Accelerate your LNP formulation screening with Sunscreen’s automated microfluidic technology Introduction used for LNP screening, the process requires the user to individually load reagents, a time consuming and potentially wasteful process, and rely on disposable, high-cost, microfluidic mixing…

Crank them out Finding the perfect LNP formulation can feel like it drags on forever. You need to figure out the best lipid mixture, the right lipid to payload ratio and the optimal flow rates to mix it all together.…

Scale it up Once you’ve found a rock-solid formulation, Sunshine helps you tune in your LNP’s size and design the perfect process to scale them up. Scout ideal flow rates, explore different mixing options, then dial in the right dilution…