Polysorbate Degradation Analysis with the AdvanceBio Surfactant Profiling HPLC Column

Application Note Biopharma/Pharma Shining Light on Polysorbate Hydrolysis by LC/ELSD Featuring the Agilent AdvanceBio Surfactant Profiling HPLC column Authors Abstract Chenchen He, Wendi A. Hale, Andrew Coffey, Andrea Angelo P. Tripodi, and Amanda McQuay Agilent Technologies, Inc. Polysorbates are surfactants…

Agilent AdvanceBio Surfactant Profiling HPLC columns In-depth characterization of surfactant and surfactant degradation in biotherapeutic applications Surfactants: Balancing the Benefits and Risks Surfactants are a vital component of biologic formulation buffers, preventing biologic aggregation and adsorption at the air-liquid interface.…

Application Note Biopharma Separation and Analysis of Polysorbate 80 in the Presence of Human Serum Immunoglobulin G Using Agilent Bond Elut Lipid Extraction SPE Cartridges Authors Sanjeewa N. Senadheera, Limian Zhao, and Derick Lucas Agilent Technologies, Inc. Abstract Protein aggregation…

Combining mass spectra, retention time modelling, and charged aerosol detection for unambiguous peak annotation and uniform-response quantitation in polysorbate profiling Denis A. Ispan1, Sara Carillo2, Jonathan Bones2, Ken Cook3, Frank Steiner1, Mauro De Pra1 1Thermo Fisher Scientific, Germering, Germany 2…