Development and optimization of LNP formulations – using the KNAUER NanoScaler

Science with Passion Systems for lipid nanoparticle (LNP) production Printed on recycled paper Impingement Jets Mixing units for high flow production of nanoparticles (LNP, microemulsions, etc.) think LNP. think KNAUER. [PANDEMIC PROVEN] Process overview PRODUCE Bioreactor PURIF Filtration Chromatography Systems…

IJM NanoScaler Pro Automated screening system for lipid nanoparticle formulation • Create your optimal formulation with automated screening for • early-stage API candidates • perfect lipid mixtures • optimal API/lipid ratio • precise flow rates • Formulation Discovery:…

Science with Passion Scaling up LNP formulation using a Reynolds number-based methodology S. Stephan, I. Regeler, P. Pietsch; [email protected] KNAUER Wissenschaftliche Geräte GmbH, Hegauer Weg 38, 14163 Berlin; www.knauer.net SUMMARY The growing importance of lipid nanoparticles (LNPs) in pharmaceutical applications…

Science with Passion Targeted LC-MS/MS detection of lipid impurities in lipid nanoparticles M. Prüfer, G. Greco; [email protected] KNAUER Wissenschaftliche Geräte GmbH, Hegauer Weg 38, 14163 Berlin; www.knauer.net SUMMARY Lipid nanoparticles (LNPs) became famous for the rapid development and largescale production…