Automated, compliance-ready, intact mass confirmation of modified oligonucleotides using an LC-MS platform

Application note | 000457 Mass Spectrometry High-throughput analysis of oligonucleotides using a single quadrupole mass spectrometer for quality control Authors Application benefits Dennis Köhler, Mauro De Pra; This work provides a simple and comprehensive quality control workflow from Thermo Fisher…

High-throughput analysis of oligonucleotides using a single quadrupole mass spectrometer for quality control Dennis Köhler, Mauro De Pra Thermo Fisher Scientific, Germering, Germany Abstract Purpose: Show step-by-step the analysis, deconvolution, and reporting of oligonucleotide synthesis quality control with a single…

TECHNICAL NOTE 73670 Quality control of oligonucleotides with a single quadrupole mass spectrometer Author: Stephan Meding Thermo Fisher Scientific, Germering, Germany Keywords: Single quadrupole mass spectrometer, ISQ EM, Vanquish Flex Binary, Chromeleon CDS, intact mass deconvolution Goal Show the benefit…

High-throughput analysis of oligonucleotides using a single quadrupole mass spectrometer for quality control Dennis Köhler, Mauro De Pra Thermo Fisher Scientific, Germering, Germany ABSTRACT Purpose: Show step-by-step the analysis, deconvolution, and reporting oligonucleotide synthesis quality control with a single quadrupole…