Enhancing detection of hemoglobin variants in clinical research using dried blood spot and high-resolution accurate mass (HRAM) Orbitrap mass spectrometry

Clinical Research Enhanced Detection of Hemoglobin Variants in Clinical Research by DBS and High-Resolution Accurate Mass (HRAM) MS Yvonne E. Song, Kerry Hassell, Ed Goucher, Jingshu Guo, and Tanis Correa Thermo Fisher Scientific, 355 River Oaks Parkway, San Jose, CA,…

Liquid Chromatograph-Mass Spectrometer LCMS-8045 Application News High Throughput Testing Method with Newborn’s DBS for Hemoglobinopathies by LCMS-8045 with ZenTech Targeted MS/MS Hemo Device Devika Tupe1, Bhaumik H Trivedi1, Pratap Rasam1, Avinash Prabhavalkar2, Madeleine Boulanger3, Martin Greffe3, Luc Voorn3 1Shimadzu Analytical…

Introduction Top-down proteomics aims to complement bottom-up proteomics by identifying proteins in a mixture (via MS2) while providing data on proteoform distribution (via MS1). Protein charge state distribution presents a technical obstacle to realizing routine data-dependent (DDA) acquisition of top-down…

Analysis of Hemoglobin Variants using an Automated Sample Preparation Workstation Coupled to LC-MS Rachel Lieberman , Brian Feild , Kevin Meyer , Nick Herold , Scott Kuzdzal 1 1 2 2 Shimadzu Scientific Instruments, Columbia, MD Perfinity Biosciences, Inc., West…