Native Mass Spectrometry of Membrane Protein-Ligand Complexes Using the SELECT SERIES™ Cyclic™ IMS

EXPANDING NATIVE MASS SPECTROMETRY CAPABILITIES FOR SOLUBLE AND MEMBRANE PROTEINS USING A QUADRUPOLE-ION MOBILITY-TIME-OF-FLIGHT MASS SPECTROMETRY SYSTEM Brad Williams1, Dale A. Cooper-Shepherd2, Mario Hensen3, Kleitos Sokratos3, Jonathan T.S. Hopper3, and James I. Langridge2 1. Waters Corporation, 34 Maple Drive, Milford,…

Application Note Accurate Collision Cross Sections From Traveling Wave Ion Mobility Measurements in Native Mass Spectrometry – A Structural Investigation of Cas9 Ribonucleoprotein Complexes Dale Cooper-Shepherd, David Langridge, Keith Richardson Waters Corporation For research use only. Not for use in…

Waters Cyclic IMS P20 Mass Spectrometer Insight—revealed, not inferred. Insight— revealed, not inferred Biological systems are inherently complex, and answering today’s research questions requires tools that can reveal that complexity with clarity. The Waters™ Cyclic™ IMS P20 Mass Spectrometer enables…

Application Note Structural Characterization of Glycated Monoclonal Antibodies Using Collision Induced Unfolding on the SELECT SERIES™ Cyclic™ IMS Mass Spectrometer Kristine Parson, Margo Wilson, Greg Adams, Jason Barker, Dale Cooper-Shepherd FUJIFILM Diosynth Biotechnologies, Waters Corporation Abstract Mass spectrometry-based methods are…