Monitoring Amino Acid and Bispecific Antibody Homodimer by LC-MS for an Accelerated Upstream Process Development using Sartorius Ambr®15 Microbioreactor

[APPLICATION NOTEBOOK] At-line Solutions for Upstream Bioprocessing Application Notes [APPLICATION NOTEBOOK] Introduction Bioprocessing harnesses the power of living cells to manufacture valuable products such as biological drugs for clinical use. The introduction and use of biologics has revolutionized biotherapeutics to…

Application Note Direct LC-MS Characterization of Glycoform Distribution and Low Molecular Weight Impurities in mAb Process from Ambr® 15 Bioreactors Lindsay Morrison, Charles Prochaska, Alireza Aghayee, Clint Kukla, Ying Qing Yu Waters Corporation, Sartorius Stedim Abstract Full characterization of Critical…

Application Note Monitoring Intact Glycoprofiles and Spent Media Metabolites in Samples from Sartorius Ambr 250 High Throughput Bioreactor System to Support Upstream Process Development Yun Wang Alelyunas, Charles Prochaska, Clint Kukla, Caitlin Dunning, Caitlin Hanna, Mark D. Wrona Waters Corporation,…

Application Note In-Process Media Monitoring Using the BioAccord™ LC-MS for the Automated High throughout Multi-Parallel Ambr®15 Microbioreactor System Yun Wang Alelyunas, Charles Prochaska, Clint Kukla, Mark D. Wrona, Ying Qing Yu Waters Corporation, Sartorius Stedim North America This is an…