Quantitation of N-Nitroso Carvedilol in Drug Substance Using LC-MS/MS

Application Note Analysis of N-Nitroso-Sertraline in Drug Substance and Tablet Using LC-MS/MS Dimple D. Shah, Marian Twohig, Matthew Gregory, Joe Lackey, Moritz Perscheid, Amy Bartlett, Peter Hancock Waters Corporation, LGC Standards Abstract N-nitrosamines have indeed become a significant concern for…

Application Note Quantitation of N-Nitroso-Propranolol in Drug Substance using LC-MS/MS Marian Twohig, Amy Bartlett, Padmakar Wagh Waters Corporation Abstract N-Nitrosamines (nitrosamines) can be potentially mutagenic and carcinogenic. Since 2018, nitrosamines have been discovered in several classes of pharmaceuticals. There have…

Application Note Quantitation of N-Nitroso-DesmethylDiltiazem, an NDSRI Impurity of Diltiazem Hydrochloride in Drug Product Using LCMS/MS Pavan Kukkadapua, Marian Twohigb, Padmakar Wagha a Waters Corporation, Bangalore, India b Waters Corporation, Milford, United States Published on August 19, 2026 Abstract Since…

Application note | 003910 Pharma Liquid chromatography – high-resolution mass spectrometry method for determination of NDSRI in six beta-blocker drug substances Authors Application benefits Varun Khali1, Manoj Kushwaha1, • A single high-resolution-based method to determine the NDSRI level in a…