Streamlining Impurity Analysis in Atorvastatin with the ACQUITY™ QDa™ II Mass Detector for Enhanced Detection and Quantification

Application Note Expediting Method Development for Oligonucleotide Impurity Analysis Using the ACQUITY™ QDa™ II Mass Detector Xiangsha Du, Robert E. Birdsall, Karen Nyholm Waters Corporation, United States Published on May 02, 2025 Abstract Therapeutic oligonucleotides such as antisense oligos, siRNAs,…

[ APPLICATION NOTEBOOK ] ACQUITY QDa Detector QC APPLICATIONS COMPENDIUM EDITION 2 Dear Colleague The 2013 introduction of the ACQUITY™ QDa™ Detector was a breakthrough in Chromatography and Mass Spectrometry integration. It was the fulfilment of a vision 20 years…

Application Note Analytical Scale Isolation and Purification of Propranolol Impurities Including Nitrosamine Drug Substance Related Impurity (NDSRI) Margaret Maziarz, Paul Rainville, Stephanie Harden Waters Corporation, United States Published on Novemebr 07, 2025 Abstract Nitrosamine drug substance-related impurities (NDSRIs) are a…

Application Note Accelerating Method Development and Manufacturing of GLP-1 Analogs with LCUV/MS Duanduan Han, Samantha Ippoliti, Robert E. Birdsall, Karen Nyholm Waters Corporation United States Published on May 14, 2025 Contact Sales Abstract Glucagon-like-peptide-1 (GLP-1) receptor agonists have recently gained…