Emerging Alternative Analytical Techniques for Oligonucleotide Separation and Purification: HILIC & SEC

Connor Flannery1, Jordy Hsiao1, Lee Bertram1, Andrea Angelo P. Tripodi2, Andrew Coffey2, Anne Blackwell 4, Ta-Chen Wei4, Chae-Young Ryu3 Emerging Alternative Analytical Techniques for Oligonucleotide Separation and Purification: HILIC & SEC Introduction 1Agilent Technologies, Santa Clara, CA 2Agilent Technologies, Church…

Poster Reprint ASMS 2024 Poster number WP 573 Systematic Evaluation of Hydrophilic Interaction Liquid Chromatography Stationary Phases for Oligonucleotide Characterization by LC/MS Jordy J. Hsiao1, Alex Apffel1, Lee Bertram1, Andrea Angelo P. Tripodi2, Andrew Coffey2, Ta-Chen Wei3, Connor Flannery1 1Agilent…

Application Note Biopharma/Pharma Evaluating HILIC Stationary Phases for Oligonucleotide Separation by LC/MS Authors Abstract Jordy Hsiao, Lee Bertram, Alex Apffel, Andrea Angelo P. Tripodi, Andrew Coffey, Ta-Chen Wei, and Connor Flannery Agilent Technologies, Inc. Hydrophilic interaction chromatography (HILIC) represents a…

Poster Reprint ASMS 2026 MP 528 Improved Oligonucleotide LC–MS Performance through Inert Column Hardware and Alternative Separation Strategies Andrew Coffey1; Daniel Meston1; Chae-Young Ryu2; Anne Blackwell2; Jordy Hsiao4 1Agilent Technlogies, Church Stretton, United Kingdom; 2 Agilent Technologies, Seoul, South Korea;…