Analysis & Purification of Therapeutic Oligonucleotides: Method development optimization from the analytical scale through semi-prep and preparative purification

Poster Reprint HPLC 2024 Poster number 275 Analysis & Purification of Therapeutic Oligonucleotides: Method Development Optimization from the Analytical Scale Through Semi-prep and Preparative Purification Connor Flannery1, Jordy Hsiao1 , Andrea Angelo P. Tripodi2, Andrew Coffey2 1Agilent Technologies, Santa Clara,…

An Introduction to Ion-Paired Reverse-Phase Oligonucleotide Separations: From Analysis to Purification Melissa Goodlad, PhD Columns and Supplies Applications Engineer April 15, 2025 1 April 15, 2025 An Introduction to Ion-Paired Reverse-Phase Oligonucleotide Separations DE-006001 Introduction to Ion-Paired Reverse-Phase (IP-RP) Separations…

An Introduction to Ion-Paired Reverse-Phase Oligonucleotide Separations: From Analysis to Purification Melissa Goodlad, PhD Columns and Supplies Applications Engineer April 15, 2025 1 April 15, 2025 An Introduction to Ion-Paired Reverse-Phase Oligonucleotide Separations DE-006001 Introduction to Ion-Paired Reverse-Phase (IP-RP) Separations…

Application Note Biopharma/Pharma Superficially Porous Columns for Semi-Preparative Purification of Synthetic Oligonucleotides Method development and scale-up using same analytical LC instrumentation Authors Abstract Andrea Angelo P. Tripodi and Andrew Coffey Agilent Technologies, Inc. Synthetic oligonucleotides inevitably contain many impurities due…