APPLICATION OF TARGETED LIPIDOMICS TO DETERMINE CHANGES IN THE PLASMA LIPIDOME OF MALE RATS FOLLOWING REPEAT ORAL ADMINISTRATION OF METHAPYRILENE

Investigating The Relationship Between Off Target Pharmacology & The DMPK of Methapyrilene Using Lipidomics And MS Imaging. Abstract ID number: 322543 Authors: 1Andrew Leightner, 1Anthony Middey, 1Steven K Lai, 1Robert S Plumb, 2Ian D Wilson Affiliations: 1Waters Corporation, Milford, MA,…

TARGETED DESI IMAGING MS OF DRUG DISTRIBUTION AND DRUGINDUCED LIVER INJURY (DILI) METABOLITES FROM METHAPYRILENE IN THE MALE WISTAR RAT Anthony Midey,1 Emmanuelle Claude,2 Lisa Reid,2 Bindesh Shrestha,1 Steven K Lai,1 Ian D Wilson,3 Robert S Plumb,1 and Roy Martin1…

Application Note LipidQuan™: A Robust LC-MS/MS Methodology for Rapidly Profiling the Lipidome of Liver Tissue Following Metabolism of the Drug Gefitinib Nyasha Munjoma, I.D. Wilson, Lee A. Gethings, Robert S. Plumb Waters Corporation For research use only. Not for use…

Application Note Constant Neutral Loss, Precursor Ion Scanning, Product Ion Scanning in Support of DMPK Studies Using waters_connect for Quantitation Software Solution and Xevo TQ Absolute XR Mass Spectrometer Robert S. Plumb, Nikunj Tanna Waters Corporation, United States Published on…