High-throughput LC/MS characterization of mRNA therapeutics using a fast DDA method on the Orbitrap Astral MS

Characterization of mRNA Therapeutics Using a Novel LC-MS Based Workflow Angela Criscuolo3, Tabiwang Arrey3, Andrew Williamson2, Ken Cook2, Keeley Murphy1, Jennifer Sutton1, Alexander Harder3, Jim Shofstahl1, Mark Sanders1 1Thermo Fisher Scientific, San Jose, CA, USA; 2Thermo Fisher Scientific, Hemel Hempstead,…

Oligonucleotide sequencing by LC-MS/MS: A novel Approach for Characterization and Quality Control of mRNA-based Vaccines and Biotherapeutics Alexander Schwahn, Angela Criscuolo, and Ken Cook The world leader in serving science 1 [email protected] | ISC2022 Why have oligonucleotides become so popular?…

Customer application note | 000723 Biotechnology mRNA direct sequence mapping using automated partial digestion with magnetic nuclease and LC-HRMS Authors Application benefits Mark Dickman1, Christina Vanhinsbergh1, Jon Bardsley , Ken Cook , Andrew 2 2 Williamson2, Jennifer Sutton3, Keeley Murphy3…

Application note | 001108 Biopharma Characterization of mRNA 5’ capping products using an LC-HRAM-MS/MS analytical platform and Thermo Scientific BioPharma Finder software solution Authors Goal Robert L Ross, Keeley Murphy, Yi Zhang, To develop a sensitive and robust LC-HRAM-MS/MS method…