Optimization of the Astral detection system: Enabling high linear dynamic range and single ion sensitivity for deep proteome coverage

Characterization of a detection system with high sensitivity and dynamic range for a novel HRAM mass spectrometer Johannes Petzoldt1, Toby Shanley1, Wilko Balschun1, Philipp Cochems1, Bernd Hagedorn1, Christian Hock1, Barak Lavi2, Daniel Mourad1, Maximilian Ochmann1, Robert Ostermann1, Semyon Shofman2, Hamish…

Time-of-Flight Mass Spectrometry Technical Overview Introduction Time-of-flight mass spectrometry (TOF MS) was developed in the late 1940’s, but until the 1990’s its popularity was limited. Recent improvements in TOF technology, including orthogonal acceleration, ion mirrors (reflectron), and high-speed electronics, have…

Time-of-Flight Mass Spectrometry Technical Overview Introduction Time-of-flight mass spectrometry (TOF MS) was developed in the late 1940’s, but until the 1990’s its popularity was limited. Recent improvements in TOF technology, including orthogonal acceleration, ion mirrors (reflectron), and high-speed electronics, have…

Enhanced resolution with multi-pass mode on the Orbitrap Astral Zoom mass spectrometer Christopher Rathje, Hamish Stewart, Bernd Hagedorn, Eduard Denisov, Robert Ostermann, Johannes Petzoldt, Daniel Mourad, Philipp Cochems, Florian Bonn, Martin Zeller, Julia Kraegenbring, Eugen Damoc, Bernard Delanghe, Michael Wiedemeyer,…