Automated online protein-ligand binding and its detection using native mass spectrometry

Application note | 003565 Native MS Gas phase affinity selection-native mass spectrometry for automated ligand screening Authors Introduction Weijing Liu , Wilson Phung , 1 Ligand screening is a critical process in drug discovery and structural biology, aimed at 2…

Multi-dimensional high-throughput molecular glue screening via gas phase affinity selection native mass spectrometry and cryo-EM analysis Weijing Liu1, Kheewoong Baek2,3, Albert Konijnenberg4, Wenfei Song4, Christopher Mullen1, Yuan Xiong2,3, Ken Durbin5, Shane Bechler6, Eric Fischer2,3, Rosa Viner1, Thomas Moehring7 1Thermo Fisher…

Studying protein-drug complexes under native conditions in the low nM range using MRMS Mass spectrometry has been used as a tool to study a wide variety of protein-ligand and other biological interactions with great success [1]. Modeling solution phase physiological…

INTRODUCTION 600 In recent years, interest in intact protein analysis by HPLC, LC-MS, and MSMS has increased significantly. This can be attributed to both improvements to LC and MS hardware, instrument control software, and data processing software. Conceptual shifts in…