Top-down characterization of genetically encoded Bcl-xL phosphorylation and phosphomimetics using electron capture dissociation

Poster Reprint ASMS 2023 Poster number MP 674 Revealing non-canonical phosphorylation of the SARS-CoV-2 nucleocapsid using top-down electron capture dissociation and sequence tag generation Rachel Franklin1,2, Phillip Zhu2, Adrian Guthals1, Joseph Meeuwsen1, Steve Madden1, Michael C. Hare1, Richard Cooley2, Joseph…

Application note | 002599 Biopharma Characterization of adeno-associated viral proteins proteoforms using a top-down MS approach on a UHPLC-Orbitrap Ascend Tribrid mass spectrometer Application benefits Authors Reiko Kiyonami , Rafael Melani , 1 1 • Confident determination of PTM localization…

Application Note Biopharma Top-Down Sequence Analysis of Intact Proteins Using an Agilent AdvanceBio 6545XT LC/Q-TOF with ExD Authors Rachel Franklin and Mike Hare Agilent Technologies, Inc. Abstract Detailed proteoform characterization is crucial for understanding disease mode of action (MOA) and…

Transformative Workflows for Protein Characterization: ECD and Multidimensional Separations Expert Insights Sponsored by Expert Insights Contents Introduction 3 The Role of Electron Capture Dissociation in Biomolecular Analysis Adapted from Cooper, et al. 4 Offline Coupling of Hydrophobic Interaction Chromatography– Capillary…