In-Source Reactivity Mass Spectrometry: Revealing Reactive Species through High-Resolution Characterization

Technical Overview Ultrafast Antibody Peptide Mapping with the Agilent 6545XT AdvanceBio LC/Q-TOF Authors Introduction Mengyuan Xiao, Yongqing Yang, Andrew Schladebeck, and Hao Chen Department of Chemistry & Environmental Science, New Jersey Institute of Technology, Newark, NJ, 07102, USA This technical…

[ APPLICATION NOTEBOOK ] APPLICATION SOLUTIONS FOR OLIGONUCLEOTIDES Table of Contents Introduction – UPLC Analysis of Synthetic Oligonucleotides......................................................................................................................... 4 [ HPLC & UPLC Separations ] Real-Time Analysis of RNAi Duplexes ....................................................................................................................................................................... 8 Semi-Preparative Scale Single-Stranded RNA Purification .......................................................................................................................... 11 Oligonucleotide…

Fast acquisition of DDA-MS/MS of oligonucleotides and the novel spectral merging algorithm for better assignment of Kosuke Uchiyama , Yoshihiro Kunimura , Simon Ashton , Richard Price , Helen Jose , Atsuhiko Toyama , Neil Loftus sequence information Shimadzu Corporation,…

Application Note Biopharma Evaluation of Different Ion-Pairing Reagents for LC/UV and LC/MS Analysis of Oligonucleotides Authors Gerd Vanhoenacker, Cindy Lecluyse, Griet Debyser, Pat Sandra, and Koen Sandra RIC Biologics Belgium Sonja Schipperges, Sonja Schneider, and Udo Huber Agilent Technologies, Inc.…