Cyclic™ Ion Mobility Unravels Sites of Chemically Induced Deamidation

Application Note Deep Characterization of Aspartic Acid Isomerism Using High-Resolution Cyclic™ Ion Mobility and Electron-Capture Dissociation Samantha Ippoliti, Brad Williams, Dale Cooper-Shepherd Waters Corporation, United States Published on January 06, 2026 Application Brief This is an Application Brief and does…

INVESTIGATING PRIMARY AND HIGHER-ORDER PROTEIN STRUCTURE ANALYSIS USING A NOVEL CYCLIC ION MOBILITY ENABLED QTOF PLATFORM Scott J. Berger1, Dale A. Cooper-Shepherd2 , Martin Palmer2, LeRoy B Martin1, Henry Shion1, and James I. Langridge2, 1 Waters Corporation, Milford, MA, 01757…

A HIGHLY VERSATILE CYCLIC ION MOBILITY – MASS SPECTROMETER FOR ROUTINE TO IN-DEPTH BIOPHARMACEUTICAL CHARACTERIZATION Brad J. Williams1, Margo Wilson2, S. Hunter Walker2, Greg Adams2, Roy Martin1, and Weibin Chen1 1 Waters Corporation, Milford, MA 01757 USA, 2FUJIFILM Diosynth Biotechnologies,…

Application Note Biotherapeutics Quantitation of Chemical-Induced Deamidation and Oxidation on Monoclonal Antibodies Using Agilent 6545XT AdvanceBio LC/Q-TOF and Agilent MassHunter BioConfirm Software Author Linfeng Wu Agilent Technologies, Inc. Santa Clara, CA, USA Introduction Modifications such as asparagine (Asn) deamidation, aspartate…