Introducing a Rapid Throughput LC-MS Method for Cell Culture Media Nutrient and Metabolite Analysis Supporting Upstream Bioprocessing

[APPLICATION NOTEBOOK] At-line Solutions for Upstream Bioprocessing Application Notes [APPLICATION NOTEBOOK] Introduction Bioprocessing harnesses the power of living cells to manufacture valuable products such as biological drugs for clinical use. The introduction and use of biologics has revolutionized biotherapeutics to…

A High Throughput LC-MS Method for Cell Culture Media Nutrient and Metabolite Analysis Supporting Upstream Bioprocessing Yun W. Alelyunas, Josh Gray, Guillaume Bechade, Courtney Walton, Mark D. Wrona, Waters Technology Corporation, Milford, MA INTRODUCTION METHODS RESULTS A 9-minute rapid and…

Application Note Analytical LC-MS Platform Methodologies to Support Upstream Bioprocess Optimization Yun Alelyunas, Julie Wushensky, Jurgen Sanes, Mark Wrona, Rui Chen Waters Corporation, United States Published on August 18, 2025 Introduction Effective process monitoring and product critical quality attribute analysis…

Application Note Monitoring Intact Glycoprofiles and Spent Media Metabolites in Samples from Sartorius Ambr 250 High Throughput Bioreactor System to Support Upstream Process Development Yun Wang Alelyunas, Charles Prochaska, Clint Kukla, Caitlin Dunning, Caitlin Hanna, Mark D. Wrona Waters Corporation,…