Interactive Design and Application of MassQL Queries after Preprocessing for the Annotation of PFAS in LC-TIMS-PASEF data

Investigating the increased lifespan in C. elegans daf-2 mutants by 4D-Lipidomics The small nematode Caenorhabditis elegans is one of the premier biomedical model organisms and employed in many aspects of basic and applied science Introduction Typical application areas for C.…

4D-Lipidomics™ workflow for increased throughput Lipid profiling from complex lipid extracts can be a challenging and time consuming task. The high complexity of samples and co-elution of isobaric or isomeric compounds complicate the confident annotation of lipids. The presented 4D-Lipidomics…

ASMS 2025 TP 474 Confident annotation of GPNAE and HexGPNAE in Caenorhabditis elegans aided by homologous series extension in LC-MS/MS data Nikolas Kessler1; Aiko Barsch1; Erica M. Forsberg1; Matthew R. Lewis1; Michael Witting2 Methods Mixed stage C. elegans reference samples…

Intensity (arb. unit) 132% 0% 100% PS 38:1 m/z 816.5747 ± 0.0122 1/K0 1.433 ± 0.01 Intensity (arb. unit) Mobility [1/K0] 136% 0% 100% PE 20:1_22:6 m/z 816.5517 ± 0.0122 1/K0 1.404 ± 0.01 m/z 1 mm CCS-aware SpatialOMx® enables…