Assessing Protein and Payload Stability of Antibody Drug Conjugate Brentuximab Vedotin in Monkey Plasma

Agilent BioHPLC columns Characterization of Antibody-Drug Conjugate Critical Quality Attributes Application compendium Contents Introduction3 Featured application notes 2 PLRP-S Polymeric Reversed-Phase Column for LC/MS Separation of mAbs and ADC (5991-7163EN) 5 Intact- and Peptide-Level Characterization of Trastuzumab Emtansine In Vitro…

Application Note Biotherapeutics & Biosimilars Drug to Antibody Ratio Analysis of Brentuximab Vedotin in Monkey Plasma Antibody drug conjugate analysis under native conditions using Agilent AdvanceBio 6545XT LC/Q-TOF systems Authors Xi Qiu and Kenda LJ Evans Agilent Technologies, Inc. Andrea…

Application Note Pharma and Biopharma A streamlined drug-to-antibody ratio determination workflow for intact and deglycosylated antibody-drug conjugates Using the Agilent AssayMAP Bravo and Agilent 6545XT AdvanceBio accurate-mass quadrupole time-of-flight LC/MS system Authors Jerry Han, Zach Van Den Heuvel, and Steve…

Application Note Biopharma Identification of Conjugation Sites in an Antibody Drug Conjugate Using the Agilent 6545XT AdvanceBio LC/Q-TOF system Author Abstract Yulan Bian Agilent Technologies, Inc. This application note highlights the workflow of drug conjugation site identification in an antibody…