FAST AND HIGH RECOVERY ANALYTICAL CHARACTERIZATION OF mRNAs USING WEAK ANION EXCHANGE AND ION PAIRING REVERSED PHASE CHROMATOGRAPHY

Application Note Salt Plug Injection Methods for Improved Anion Exchange Analyses of Large Nucleic Acids Szabolcs Fekete, Matthew A. Lauber Waters Corporation Abstract With a burgeoning pipeline of nucleic acid-based therapies, there is a need for improved analytical methods that…

Application Note Methods for the Anion Exchange Chromatographic Analysis of mRNAs Szabolcs Fekete, Hua Yang, Stephan M. Koza, Kevin Wyndham, Matthew A. Lauber Waters Corporation Abstract mRNA-based therapeutics and vaccines are a relatively new class of biopharmaceuticals that have demonstrated…

Application Note Biopharma/Pharma Wide Pore Polymeric Reversed-Phase PLRP-S Columns for mRNA Analysis Experimental parameters and comparative analytical outcomes using different molecule sizes Author Abstract Jennifer Bouchenna, Claire Butré, Damien Mouvet, and Arnaud Delobel Since the discovery of effective methods of…

CONSUMABLES GUIDE BOOK Characterizing LNP mRNA LC tools for purity, identity, integrity and concentration determining measurements A Changing Industry mRNA based medicine helped address the COVID-19 pandemic. The viability of using an mRNA construct as a human drug substance has…