Simple charge variant profile comparison of an innovator monoclonal antibody and a biosimilar candidate

APPLICATION NOTE 21778 Evaluation and application of salt- and pH-based ion-exchange chromatography gradients for analysis of therapeutic monoclonal antibodies Authors Amy Farrell, Craig Jakes, and Jonathan Bones Characterization and Comparability Laboratory, NIBRT – The National Institute for Bioprocessing Research and…

APPLICATION NOTE 21684 K KK Using the NISTmAb reference standard to demonstrate a simple approach to charge variant analysis Authors Silvia Millán, Amy Farrell, and Jonathan Bones Characterisation and Comparability Laboratory, NIBRT – The National Institute for Bioprocessing Research and…

Shanhua Lin and Chris Pohl, Thermo Fisher Scientific, Sunnyvale, CA, USA Key Words Rituxan, rituximab, Herceptin, trastuzumab, Humira, adalimumab, Avastin, bevacizumab, CX-1 pH Gradient Buffer Kit, MAbPac SCX-10, mAb charge variant analysis Goal To develop a high-resolution charge variant analysis…

Chromatographic Workflows for Biopharmaceutical Characterization Dr. Ken Cook European Bioseparation Sales Support Expert Thermo Fisher Scientific, Hemel Hempstead/Germany The world leader in serving science Fulfilling the Needs of Biotherapeutic Characterization Charge variant screening Peptide mapping Released glycan analysis Aggregate screening…