Determination of molecular weight of small interfering nucleotides siRNA by LCMS (ASMS)

TP 507 Determination of molecular weight of small interfering nucleotides siRNA by LCMS Jia Zheng1, Qiaxia Liu1, Hongyuan Hao1, Taohong Huang1 1 Shimadzu (China) Co., Ltd., Shanghai, China. (x10,000,000) 1:TIC(-) 1. Overview In order to remove the additive ions in…

A Software Workflow Using Wide Mass Range Single Quadrupole Mass Spectrometry Data Stream Applied to Oligonucleotides Confirmation Risa Suzuki1, 2, Kosuke Uchiyama2, Noriko Kato2, Yuka Fujito2, Jeffery Dahl1, Simon Ashton3, Neil Loftus3, Atsuhiko Toyama2, 4 1Shimadzu Scientific Instruments, Inc., Columbia,…

Application Note Biopharma Complementary LC/MS and UV‑Vis Spectrophotometry for siRNA Quality Control and Thermal Stability Assessment Authors Abstract Yulan Bian and Ravindra Gudihal Agilent Technologies, Inc. Small interfering RNAs (siRNAs) are increasingly important therapeutic agents, which require robust analytical strategies…

C10G-E097 Oligonucleotide Therapeutics Solution Guide Types and Characteristics of Oligonucleotide Therapeutics Oligonucleotide therapeutics are nucleic acid polymers generally comprised of a few to several dozen bases However, it is a practical problem that oligonucleotide therapeutics are degraded and excreted rapidly…