SCREENING FOR EXTRACTABLES AND LEACHABLES IN NASAL SPRAY DEVICES USING HIGH-RESOLUTION MASS SPECTROMETRY COMBINED WITH A DATA INDEPENDENT INFORMATICS STRATEGY

ADDRESSING THE CHALLENGES OF EXTRACTABLES AND LEACHABLES SCREENING USING HIGH-RESOLUTION QUADRUPOLE TIME OF FLIGHT Rachel Sanig1, Jayne Kirk1, Cristian Cojocariu1, Andrew Feilden2 Waters Corporation,, Altrincham Road, Wilmslow, Cheshire, SK9 4AX, UK1, Hall Analytical Laboratories Ltd., Waterside Court, 1 Crewe Road,…

ENSURING CONFIDENT ANALYSIS OF EXTRACTABLES AND LEACHABLES USING HIGH-RESOLUTION QUADRUPOLE TIME OF FLIGHT TECHNOLOGY Gordon Kearney1, Rachel Sanig1, Jayne Kirk1, Cristian Cojocariu1, Andrew Feilden2 Waters Corporation,, Altrincham Road, Wilmslow, Cheshire, SK9 4AX, UK1, Hall Analytical Laboratories Ltd., Waterside Court, 1…

EXTRACTABLES ANALYSIS OF NASAL SPRAY DEVICES USING GAS CHROMATOGRAPHY AND QUADRUPOLE TIME OF FLIGHT HIGH-RESOLUTION MASS SPECTROMETRY WITH SOFT IONIZATION Rachel Sanig, Hania Khoury-Hollins, Jayne Kirk, Lee Gethings, Richard Lock Waters Corporation, Altrincham Road, Wilmslow, Cheshire, SK9 4AX, UK INTRODUCTION…

Application Note Extractables Analysis of Nasal Spray Devices Using Gas Chromatography and HighResolution Mass Spectrometry With Soft Ionization Rachel Sanig, Sarah Dowd, Jayne Kirk Waters Corporation Abstract Due to concern about the safety of components from plastic, it is crucial…