Determination of Sulfate and Sulfamate in Topiramate Using a Reagent-Free Ion Chromatography System

Brian De Borba and Jeffrey Rohrer Thermo Fisher Scientific, Sunnyvale, CA, USA Keywords Drug Substance, Active Pharmaceutical Ingredient (API), Dionex IonPac AS18 2 mm Column, Suppressed Conductivity Detection Introduction Nearly half of all pharmaceuticals are produced in their salt form.…

Application Note 190 Determination of Sulfate Counter Ion and Anionic Impurities in Aminoglycoside Drug Substances by Ion Chromatography with Suppressed Conductivity Detection INTRODUCTION Most drug substances are produced synthetically in bulk and formulated into convenient dosage forms, such as tablets,…

Application Note 190 Determination of Sulfate Counter Ion and Anionic Impurities in Aminoglycoside Drug Substances by Ion Chromatography with Suppressed Conductivity Detection INTRODUCTION Most drug substances are produced synthetically in bulk and formulated into convenient dosage forms, such as tablets,…

TECHNICAL NOTE 45 Determination of trace anions in hydrofluoric acid, ammonium fluoride, and a buffered oxide etchant Authors T. Phesatcha, S. Tukkeeree, and J. Rohrer Thermo Fisher Scientific, Sunnyvale, CA Keywords Ion chromatography, IC, ionexclusion pre-separation, ICE, ICE-AS1, chloride, nitrate,…