A Novel LC-MS/MS Method for the Analysis of Antidepressants in Plasma for Clinical Research

A CLINICAL RESEARCH LC-MS/MS METHOD FOR THE ANALYSIS OF ANTIDEPRESSANTS IN PLASMA B-339 L Calton, G Hammond, R Wardle and S Balloch Waters Corporation, Wilmslow, Cheshire, SK9 4AX, UK INTRODUCTION Depression is common globally, with an estimated 3.8% of the…

TECHNICAL NOTE 21966 Clinical research method for the quantitative determination of free plasma serotonin and 5-hydroxyindoleacetic acid (5-HIAA) in human plasma by UHPLC-MS/MS Authors Callum Taylor and Kean Woodmansey Thermo Fisher Scientific, Runcorn, UK Keywords Acclaim Vanquish, serotonin, SSRIs, plasma,…

ANALYSIS OF TRICYCLIC ANTIDEPRESSANT DRUGS IN PLASMA FOR CLINICAL RESEARCH Vallerie Muckoya1, Lisa J Calton1, Gareth Hammond1 and Padhraic Rossiter2 (1) Waters Corporation, Wilmslow, Cheshire, UK; (2) Waters Technologies Ireland Ltd., Drinagh, Wexford, Ireland INTRODUCTION Fast quantification of 15 TCAs…

A Novel LC-MS/MS Method for the Analysis of Antibiotics in Plasma for Clinical Research David Ballantyne, Waters Background: A reliable clinical research method for the analysis of a large number of antibiotics in a single sample may play a role…