Size-Exclusion Chromatography Method for Poly(A) Tail Analysis of mRNA

Application Note Ion-Pair Reversed-Phase Liquid Chromatography Method for Analysis of mRNA Poly(A) Tail Heterogeneity Martin Gilar, Maissa M. Gaye Waters Corporation Abstract Messenger RNA (mRNA) biopolymers are new therapeutic modalities. Development of effective mRNA vaccines against SARS-CoV-2 virus accelerated the…

CONSUMABLES GUIDE BOOK Characterizing LNP mRNA LC tools for purity, identity, integrity and concentration determining measurements A Changing Industry mRNA based medicine helped address the COVID-19 pandemic. The viability of using an mRNA construct as a human drug substance has…

Application Note LC-MS Analysis of Two mRNA Critical Quality Attributes: 5’-Capping Efficiency and Average Poly(A) Tail Length and Heterogeneity Using the Xevo™ MRT Mass Spectrometer Catalin Doneanua, Alexandre F. Gomesa, Jo-Anne Rileyb, Ying Qing Yua a Waters Corporation, United States…

Application Note Head to Tail Analysis of mRNA by RapiZyme™ MC1 and Cusativin Alexandre F. Gomes*, Tatiana Johnston*, Balasubrahmanyam Addepalli * Equal contribution Waters Corporation, United States Published on August 10, 2026 Abstract Head to Tail Analysis of mRNA by…