Application Note 262 Determination of 2-Ethylhexanoic Acid Impurity in Clavulanate INTRODUCTION Clavulanic acid is a potent beta-lactamase inhibitor that when used in combination with penicillin and cephalosporin antibiotics, increases their effectiveness by counteracting bacterial resistance.1, 2 Clavulanic acid is produced…
Key words
clavulanate, potassium, api, degassed, lactamase, beta, standards, criterion, monograph, peak, chromatography, clavuligerus, surrogate, acid, minutes