Characterizing and Monitoring Impurities in Lipid Nanoparticle Components Using the BioAccord™ LC-MS System with waters_connect™ Software

M1030-01-02 Identification and Characterization of Impurities in Lipid Nanoparticle Components Using TOF-MS with Predictive In-silico Fragmentation and Automated Data Processing Kellen DeLaney, Duanduan Han, Robert E. Birdsall, Ying Qing Yu, Ann Gray Waters Corporation, Milford, MA PURPOSE The development of…

Application Note Rapid Analysis of Lipid Nanoparticle Components Using BioAccord LC-MS System Giorgis Isaac, Nilini Ranbaduge, Bonnie A. Alden, Colette Quinn, Weibin Chen, Robert S. Plumb Waters Corporation Abstract The recent success of mRNA vaccines for COVID-19 is in part…

Rapid Analysis and Characterization of Lipid Nanoparticle Components for mRNA Delivery W0930-09-49 Giorgis Isaac, Nilini Ranbaduge, Suraj Dhungana Waters Corporation, 34 Maple Street, Milford, Massachusetts, USA CONTACT INFORMATION: [email protected] PURPOSE Success of mRNA vaccines for SARS-CoV-2 highlight the potential of…

Application Note Lipid Nanoparticle Analysis: Leveraging MS to Reduce Risk Duanduan Han, Kellen DeLaney, Bonnie A. Alden, Robert E. Birdsall, Ying Qing Yu Waters Corporation Abstract Lipid nanoparticles (LNPs) represent an elegant solution in the delivery of gene-based therapeutics that…