Oligonucleotide Analysis with Ion-Pair Reversed-Phase Chromatography and Agilent 1260 Infinity II Prime LC

An Introduction to Ion-Paired Reverse-Phase Oligonucleotide Separations: From Analysis to Purification Melissa Goodlad, PhD Columns and Supplies Applications Engineer April 15, 2025 1 April 15, 2025 An Introduction to Ion-Paired Reverse-Phase Oligonucleotide Separations DE-006001 Introduction to Ion-Paired Reverse-Phase (IP-RP) Separations…

An Introduction to Ion-Paired Reverse-Phase Oligonucleotide Separations: From Analysis to Purification Melissa Goodlad, PhD Columns and Supplies Applications Engineer April 15, 2025 1 April 15, 2025 An Introduction to Ion-Paired Reverse-Phase Oligonucleotide Separations DE-006001 Introduction to Ion-Paired Reverse-Phase (IP-RP) Separations…

Application Note Biopharma/Pharma Oligonucleotide Analysis Using the Agilent InfinityLab Pro iQ and Altura Oligo HPH-C18 Column Author Abstract Chae-Young, Ryu Agilent Technologies, Inc. The LC/MS analysis of oligonucleotides typically requires the use of alkylamine‑based ion-pairing agents to achieve adequate retention…

Application Note Biopharmaceuticals Analysis of Oligonucleotides with Ion Exchange Chromatography and Agilent Infinity II UHPLC Authors Abstract Chae-Young Ryu and Brian Liau Agilent Technologies, Inc. Although oligonucleotide analysis is frequently conducted using ion-pair reversed‑phase chromatography, ion exchange chromatography can be…