Highly Sensitive Quantification of Mutagenic NDSRI N-Nitroso Propranolol in Propranolol API and 40 mg Tablets Using LC/MS/MS

Application Note Pharmaceuticals Quantitation of N-Nitroso N-Desmethyl Diphenhydramine in Diphenhydramine HCl API Using the Agilent 6475A triple quadrupole LC/MS system Authors Abstract Prasanth Joseph, Sandeep Choudhary, Vivek Dhyani, Saikat Banerjee, and Kannan Balakrishnan Agilent Technologies, Inc. A highly specific, sensitive,…

Application Note Pharmaceutical Small Molecules Simultaneous Determination of Eight Nitrosamine Impurities in Metformin Extended-Release Tablets Using the Agilent 6470 Triple Quadrupole LC/MS Detection of regulated genotoxic impurities from the drug manufacturing process Authors Chander Mani, Kartheek Srinivas Chidella, Saikat Banerjee,…

Application Note Pharmaceuticals Highly Sensitive LC/MS/MS Method for the Simultaneous Quantification of Mutagenic Azido Impurity Analogues in Five Different Sartan APIs and Formulations Detection of regulated genotoxic impurities from the drug manufacturing process Authors Kartheek Srinivas Chidella, Saikat Banerjee, and…

[ BROCHURE ] SUPPORTING THE CHALLENGE OF NITROSAMINE DRUG SUBSTANCE RELATED IMPURITIES ANALYSIS N-Nitrosamines are potentially mutagenic impurities that may pose a risk of cancer to humans when exposed over a prolonged period. Since 2018, global regulatory bodies have required…