Analysis of Metformin and its Impurities Using Hydrophilic Interaction Liquid Chromatography (HILIC) Coupled With Ultraviolet (UV) and Mass Spectrometry (MS) Detection

A UPLC Method for Analysis of Metformin and Related Substances by Hydrophilic Interaction Chromatography (HILIC) Michael D. Jones1 and Ben William2 1 Waters Corporation, Milford, MA, USA 2 Valeant Pharmaceuticals International, Steinbach, Manitoba, Canada A P P L I C…

[ APPLICATION NOTEBOOK ] METHOD DEV ELOPMENT The Path to Successful Drug Development Starts with Purposeful Method Development [ INTRODUCTION ] T he Path to Successful Drug Development Starts with Purposeful Method Development The goal of method development in pharmaceutical…

Application Note Analysis of Creatine and Creatinine in Dietary Supplements Using HILIC-MS Kenneth Berthelette, Euan Ross, Thomas H Walter Waters Corporation, United States Published on August 14, 2026 Abstract A hydrophilic interaction liquid chromatography-mass spectrometry (HILIC-MS) method was developed to…

Application Note Analysis of Free Inositol Stereoisomers in Dietary Supplements by Hydrophilic Liquid Chromatography using the Arc™ Premier System and ACQUITY™ QDa™ II Mass Detector Jinchuan Yang, Stephanie Harden, Paul Rainville Waters Corporation, United States Published on December 24, 2025…