Quantification of Drug Metabolites in Early-Stage Drug Discovery Testing

Application note | 004316 Pharma Early-stage drug metabolite quantitation without radiolabels Authors Application benefits Katherine Lovejoy and Sylvia Grosse; • Method allows quantitation of metabolites without radiolabeling. • Method is ideal for quantitation of metabolites early in the drug development…

Use of Charged Aerosol Detection as an Orthogonal Quantification Technique for Drug Metabolites in Safety Testing (MIST) Christopher Crafts, Bruce Bailey, Marc Plante, John Waraska, Paul Gamache, and Ian Acworth ESA—A Dionex Company, Chelmsford, MA, USA Abstract INTRODUCTION The publication…

Improving the Quantitation of Unknown Impurity Analysis Using Dual-Gradient HPLC with Charged Aerosol Detection Christopher Crafts, Bruce Bailey, Marc Plante, John Waraska, and Ian Acworth ESA—A Dionex Company, Chelmsford, MA USA ABSTRACT INTRODUCTION Quantification of substances such as drug impurities…

Table of contents Summary Overview Excipient function Measurement Charged Aerosol Detector Universal detection Uniform response Working principles (U)HPLC Systems with CAD Columns choice Excipients overview Adjuvants Amino acids Carbohydrates Counterions Nonionic surfactants Polyethylene glycol Proteins and excipients HPLC-Charged Aerosol Detection…